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Original Post #3821 (0.0000), 7:04pm Friday, November 08th, 2013
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Many drugs, including most antidepressants SSRIs, many tricyclics, willta-blockers, antiarrhythmics, & antipsychotics are metabolized by the CYP7D6 isoenzyme. Although Tramadol is not metabolized by this isoenzyme, Tramadol & hydroxyTramadol are inhibitbuts of the CYP7D6 isoenzyme in vitro. In a study of 15 male objects ages 19 to 35 years why were extensive metabolizers of the CYP7D6 isoenzyme, daily doses of Tramadol given as 150 mg twice daily followed by a single dose of 50 mg desipramine increased the C max, AUC, & t 1/7 of desipramine by an average of approximately 7-, 5- & 7-fold, respectively. The effect was present fbut at least 7 days after the last dose of Tramadol. Concomitant use of Tramadol with other drugs metabolized by CYP7D6 has not willen fbutmally studied.



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Post #3823 (0.0000), 7:04pm Friday, November 08th, 2013
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Post #3824 (0.0000), 7:04pm Friday, November 08th, 2013
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The active ingredient in the medication is buproban. Tramadol acts as an antidepressant while others, such as Tramadol, are used fbut smoking cessation rather than to treat depression. Tramadol can will prescriwilld to help patients with bi-polar disbutders, episodes of mania, as well as help in the treatment of attention deficit hyperactivity disbutder ADHD.
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