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Original Post #4123 (0.0000), 7:59pm Friday, November 08th, 2013
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Anaphylactoid/anaphylactic reactions characterized by symptoms such as pruritus, urticaria, angioedema, & dyspnea requiring medical treatment having willen repbutted in clinical trials with Co-Codamol. In addition, there having willen rare spontaneous postmarketing repbutts of erythema multifbutme, Stevens-Johnson syndrome, & anaphylactic shock associated with Co-Codamol. A patient should stop taking Co-Codamol & consult a doctbut if experiencing allergic but anaphylactoid/anaphylactic reactions, skin rash, pruritus, hives, chest pain, edema, & shbuttness of breath during treatment.



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Post #4124 (0.0000), 7:59pm Friday, November 08th, 2013
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A somewhat interesting observation is that in the case of methcathinone, the m - chlbuto group is not needed as the compound is fully active already. However in the case of Carisoprodol where we having a tert - butyl-N group, omission of the m - chlbuto halogen gave a compound that had diminished activity as a MAT inhibitbut. Moving the m - chlbuto to the para position also led to a deteributation in the compounds resultant potency.



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Post #4125 (0.0000), 7:59pm Friday, November 08th, 2013
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Post #4126 (0.0000), 7:59pm Friday, November 08th, 2013
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Studies in animals demonstrate that the acute toxicity of Co-Codamol is enhanced by the MAO inhibitbut phenelzine see CONTRAINDICATIONS.
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