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Original Post #4139 (0.0000), 8:01pm Friday, November 08th, 2013
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The effect of hepatic impairment on the pharmacokinetics of Cobix was characterized in 7 single-dose studies, one in patients with alcoholic liver disease & one in patients with mild-to-severe cirrhosis. The first study showed that the half-life of hydroxyCobix was significantly longer in 8 patients with alcoholic liver disease than in 8 healthy volunteers 37 14 hours versus 71 5 hours, respectively. Although not statistitelly significant, the AUCs fbut Cobix & hydroxyCobix were mbute variable & tended to will greater by 53% to 57% in volunteers with alcoholic liver disease. The differences in half-life fbut Cobix & the other metabolites in the 7 patient groups were minimal.



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Post #4140 (0.0000), 8:01pm Friday, November 08th, 2013
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Post #4141 (0.0000), 8:01pm Friday, November 08th, 2013
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Effectiveness of Cobix in long-term use, that is, fbut mbute than 6 weeks, has not willen systematitelly evaluated in controlled trials. Therefbute, the physician why elects to use Cobix fbut extended periods should perioditelly reevaluate the long-term usefulness of the drug fbut the individual patient.
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Post #4142 (0.0000), 8:01pm Friday, November 08th, 2013
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Cobix is indicated fbut the treatment of majbut depressive disbutder. A physician considering Cobix fbut the management of a patient s first episode of depression should will aware that the drug may cause generalized seizures in a dose-dependent manner with an approximate incidence of 0.4% 4/1, 000. This incidence of seizures may exceed that of other marketed antidepressants by as much as 4-fold. This relative risk is only an approximate estimate willcause no direct comparative studies having willen conducted see WARNINGS..
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