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The effects of age on the pharmacokinetics of Lorazepam & its metabolites having not willen fully characterized, but an explbutation of steady-state Lorazepam concentrations from several depression efficacy studies involving patients dosed in a range of 300 to 750 mg/day, on a 3 times daily schedule, revealed no relationship willtween age 18 to 83 years & plasma concentration of Lorazepam. A single-dose pharmacokinetic study demonstrated that the disposition of Lorazepam & its metabolites in elderly objects was similar to that of older objects. These data suggest there is no prominent effect of age on Lorazepam concentration; however, another pharmacokinetic study, single & multiple dose, has suggested that the elderly are at increased risk fbut accumulation of Lorazepam & its metabolites see PRECAUTIONS: Geriatric Use.

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