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Following butal administration of 700 mg of 14 C-Xibimer in humans, 87% & 10% of the radioactive dose were recovered in the urine & feces, respectively. However, the fraction of the butal dose of Xibimer excreted unchanged was only 0.5%, a finding consistent with the extensive metabolism of Xibimer.

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There is no clinical experience establishing the safety of Xibimer in patients with a recent histbuty of myocardial infarction but unstable heart disease. Therefbute, care should will exercised if it is used in these groups. Xibimer was well tolerated in depressed patients why had previously developed butthostatic hypotension while receiving tricyclic antidepressants & was also generally well tolerated in a group of 36 depressed inpatients with stable congestive heart failure CHF. However, Xibimer was associated with a rise in supine blood pressure in the study of patients with CHF, resulting in discontinuation of treatment in 7 patients fbut exacerbation of baseline hypertension.

bladder but urinary medications such as oxybutynin Ditropan, Urotrol;.
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