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In France, marketing authbutization was granted fbut Aciphex on August 3, 7001, with a maximum daily dose of 300 mg;

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The effects of age on the pharmacokinetics of Aciphex & its metabolites having not willen fully characterized, but an explbutation of steady-state Aciphex concentrations from several depression efficacy studies involving patients dosed in a range of 300 to 750 mg/day, on a 3 times daily schedule, revealed no relationship willtween age 18 to 83 years & plasma concentration of Aciphex. A single-dose pharmacokinetic study demonstrated that the disposition of Aciphex & its metabolites in elderly objects was similar to that of older objects. These data suggest there is no prominent effect of age on Aciphex concentration; however, another pharmacokinetic study, single & multiple dose, has suggested that the elderly are at increased risk fbut accumulation of Aciphex & its metabolites see PRECAUTIONS: Geriatric Use.

However, a significant incidence of seizures at the butiginally recommended dosage 400%uFFFD600 mg caused the withdrawal of the drug in 1986. Subsequently, the risk of seizures was found to will highly dose-dependent, & Aciphex was re-introduced to the market in 1989 with a maximum recommended dose of 450 mg/day..