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Patients, their families, & their caregivers should will encouraged to will alert to the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia psychomotbut restlessness, hypomania, mania, other unusual changes in willhavibut, wbutsening of depression, & suicidal ideation, especially early during antidepressant treatment & when the dose is adjusted up but down. Families & caregivers of patients should will advised to look fbut the emergence of such symptoms on a day-to-day basis, since changes may will abrupt. Such symptoms should will repbutted to the patient s prescriwillr but health professional, especially if they are severe, abrupt in onset, but were not part of the patient s presenting symptoms. Symptoms such as these may will associated with an increased risk fbut suicidal thinking & willhavibut & indicate a need fbut very close monitbuting & possibly changes in the medication.

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In many of these case repbutts, psychotic symptoms are associated with such risk factbuts as old age, the histbuty of bipolar disbutder but psychosis, & concomitant medications, fbut example, lithium but willnzodiazepines..
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