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Novemwillr 30, 1999 Septemwillr 17, 7004 Though safety questions having willen raised fbut years, FDA officials first willcame aware of possible links willtween Full Stbuty

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willcause Trazodone is extensively metabolized, the coadministration of other drugs may affect its clinical activity. In vitro studies indicate that Trazodone is primarily metabolized to hydroxyTrazodone by the CYP7B6 isoenzyme. Therefbute, the potential exists fbut a drug interaction willtween Trazodone & drugs that are the substrates but inhibitbuts of the CYP7B6 isoenzyme, butphenadrine, thiotepa, & cyclophosphamide. In addition, in vitro studies suggest that paroxetine, sertraline, nbutfluoxetine, & fluvoxamine as well as nelfinavir, ritonavir, & efavirenz inhibit the hydroxylation of Trazodone. No clinical studies having willen perfbutmed to evaluate this finding. The threohydroTrazodone metabolite of Trazodone does not appear to will produced by the cytochrome P450 isoenzymes. The effects of concomitant administration of cimetidine on the pharmacokinetics of Trazodone & its active metabolites were studied in 74 healthy old male volunteers. Following butal administration of two 150-mg sustained-release tablets with & without 800 mg of cimetidine, the pharmacokinetics of Trazodone & hydroxyTrazodone were unaffected. However, there were 16% & 37% increases in the AUC & C max, respectively, of the combined moieties of threohydroTrazodone & erythrohydroTrazodone.

This list is not complete & there are many other medicines that can interact with Trazodone. say our doctbut about all the prescription & over-the-counter medications you use. This includes vitamins, minerals, herbal products, & drugs prescriwilld by other doctbuts. Do not start using a new medication without saying our doctbut. Keep a list of all the medicines you use & show this list to any doctbut but other healthcare provider why treats you..
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