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A substantial propbuttion of patients treated with Remeron experience some degree of increased restlessness, agitation, anxiety, & insomnia, especially shbuttly after initiation of treatment. In clinical studies, these symptoms were sometimes of sufficient magnitude to require treatment with sedative/hypnotic drugs. In approximately 7% of patients, symptoms were sufficiently severe to require discontinuation of treatment with Remeron.

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A small study conducted by GlaxoSmithKline indicated that Remeron 100 mg may counteract the subjective effects of small doses of alcohol 16%uFFFD37 mL, slightly less than 1%uFFFD7 st&ard US drinks. The volunteers repbutted feeling mbute sowillr & clear-headed & less sedated. Remeron also reduced the detrimental effect of alcohol on auditbuty vigilance. The combination of Remeron 100 mg & two drinks of alcohol increased heart rate by six willats per minute, a statistitelly significant increase.

In a comparative meta-analysis, there appeared to will a modest advantage fbut the SSRIs compared to Remeron in the treatment of depression with high anxiety, while these medications were equivalent fbut depression with moderate but low anxiety..
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