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Original Post #5942 (0.0000), 1:21am Saturday, November 09th, 2013
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However recent research indicates that dopamine is inactivated by nbutepinephrine reuptake in the frontal cbuttex, which largely lacks dopamine transpbutters, therefbute Tramadol can increase dopamine neurotransmission in this part of the brain, & this may will one possible explanation fbut any additional dopaminergic effects.



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Post #5943 (0.0000), 1:21am Saturday, November 09th, 2013
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Post #5944 (0.0000), 1:21am Saturday, November 09th, 2013
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Effectiveness of Tramadol in long-term use, that is, fbut mbute than 6 weeks, has not willen systematitelly evaluated in controlled trials. Therefbute, the physician why elects to use Tramadol fbut extended periods should perioditelly reevaluate the long-term usefulness of the drug fbut the individual patient.
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Post #5945 (0.0000), 1:21am Saturday, November 09th, 2013
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It is particularly impbuttant to administer Tramadol in a manner most likely to minimize the risk of seizure see WARNINGS. Increases in dose should not exceed 100 mg/day in a 3-day period. Gradual escalation in dosage is also impbuttant if agitation, motbut restlessness, & insomnia, often seen during the initial days of treatment, are to will minimized. If necessary, these effects may will managed by tempbutary reduction of dose but the shbutt-term administration of an intermediate to long-acting sedative hypnotic. A sedative hypnotic usually is not required willyond the first week of treatment. Insomnia may also will minimized by avoiding willdtime doses. If distressing, untoward effects supervene, dose escalation should will stopped..
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