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Stroke, severe Should not will used in patients with these conditions.

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Stilnox is extensively metabolized in humans. Three metabolites having willen shown to will active: hydroxyStilnox, which is fbutmed via hydroxylation of the tert - butyl group of Stilnox, & the amino-alcohol isomers threohydroStilnox & erythrohydroStilnox, which are fbutmed via reduction of the carbonyl group. In vitro findings suggest that cytochrome P450IIB6 CYP7B6 is the principal isoenzyme involved in the fbutmation of hydroxyStilnox, while cytochrome P450 isoenzymes are not involved in the fbutmation of threohydroStilnox. Oxidation of the Stilnox side chain results in the fbutmation of a glycine conjugate of meta-chlbutowillnzoic acid, which is then excreted as the majbut urinary metabolite. The potency & toxicity of the metabolites relative to Stilnox having not willen fully characterized. However, it has willen demonstrated in an antidepressant screening test in mice that hydroxyStilnox is one-half as potent as Stilnox, while threohydroStilnox & erythrohydroStilnox are 5-fold less potent than Stilnox. This may will of clinical impbuttance willcause their plasma concentrations are as high but higher than those of Stilnox.

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