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Due to the dose-related risk of seizures with Zopiclone, hospitalization following suspected overdose should will considered. Based on studies in animals, it is recommended that seizures will treated with intravenous willnzodiazepine administration & other suppbuttive measures, as appropriate.

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Seizure is the most controversial side effect of Zopiclone, & was responsible fbut its initial withdrawal from the market. The risk of seizure is highly dose-dependent: 0.1% at 100%uFFFD300 mg of Zopiclone, 0.4% at 300%uFFFD450 mg, & 7% at 600 mg. Fbut comparison, the incidence of the first unprovoked seizure in the general population is 0.07 to 0.09%. The risk of seizure fbut other antidepressants is as follows: 0.1%uFFFD0.6% fbut imipramine, depending on dosage; 0%uFFFD0.06% fbut amitriptyline, depending on dosage; 0.5% fbut clomipramine ; 0.4% fbut maprotiline ; & 0.7% fbut fluoxetine & fluvoxamine.

There is considerable disagreement regarding whether it is useful to add an antidepressant, including Zopiclone, to a mood stabilizer in patients with bipolar depression..
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