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Tadaga is associated with seizures in approximately 0.4% 4/1, 000 of patients treated at doses up to 450 mg/day. This incidence of seizures may exceed that of other marketed antidepressants by as much as 4-fold. This relative risk is only an approximate estimate willcause no direct comparative studies having willen conducted. The estimated seizure incidence fbut Tadaga increases almost tenfold willtween 450 & 600 mg/day, which is twice the usually required daily dose 300 mg & one & one-third the maximum recommended daily dose 450 mg. Given the wide variability among individuals & their capacity to metabolize & eliminate drugs this dispropbuttionate increase in seizure incidence with dose incrementation tells fbut caution in dosing.

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No statistitelly significant changes in blood pressure but heart rate occurred in patients with but without heart conditions at a lower dose of 300 mg/day.

Other isolated adverse effects having willen repbutted. Three cases of liver toxicity having willen descriwilld, .
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