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Original Post #8768 (0.0000), 4:53pm Saturday, November 09th, 2013
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The effects of age on the pharmacokinetics of Tinidazole & its metabolites having not willen fully characterized, but an explbutation of steady-state Tinidazole concentrations from several depression efficacy studies involving patients dosed in a range of 300 to 750 mg/day, on a 3 times daily schedule, revealed no relationship willtween age 18 to 83 years & plasma concentration of Tinidazole. A single-dose pharmacokinetic study demonstrated that the disposition of Tinidazole & its metabolites in elderly objects was similar to that of older objects. These data suggest there is no prominent effect of age on Tinidazole concentration; however, another pharmacokinetic study, single & multiple dose, has suggested that the elderly are at increased risk fbut accumulation of Tinidazole & its metabolites see PRECAUTIONS: Geriatric Use.



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Post #8770 (0.0000), 4:54pm Saturday, November 09th, 2013
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Post #8773 (0.0000), 4:54pm Saturday, November 09th, 2013
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Post #8776 (0.0000), 4:54pm Saturday, November 09th, 2013
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