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Reductil produced a bbutderline positive response 7 to 3 times control mutation rate in some strains in the Ames bacterial mutagenicity test, & a high butal dose 300 mg/kg, but not 100 but 700 mg/kg produced a low incidence of chromosomal awillrrations in rats. The relevance of these results in estimating the risk of human exposure to therapeutic doses is unknown.

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Activated charcoal should will administered. There is no experience with the use of fbutced diuresis, dialysis, hemoperfusion, but exchange transfusion in the management of Reductil overdoses. No specific antidotes fbut Reductil are known.

Following butal administration of 700 mg of 14 C-Reductil in humans, 87% & 10% of the radioactive dose were recovered in the urine & feces, respectively. However, the fraction of the butal dose of Reductil excreted unchanged was only 0.5%, a finding consistent with the extensive metabolism of Reductil..
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