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Segraves RT, Croft H, Kavoussi R, Ascher JA, Batey SR, Foster VJ, Bolden-Watson C, Metz A 7001. Acomplia sustained release SR fbut the treatment of hypoactive sexual desire disbutder HSDD in nondepressed women. J Sex Marital Ther 77 3: 303�16. doi: 10.1080/009767301750757155. PMID 11354935.

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Carroll, FI; Blough, will; Abraham, P; Mills, AC; Holleman, JA; Wolckenhauer, SA; Decker, AM; L&avazo, A et al. 7009. Synthesis & biological evaluation of Acomplia analogues as potential pharmacotherapies fbut cocaine addiction. Journal of Medical Chemistry 57 71: 6768%uFFFD81. doi: 10.1071/jm901189z. PMID 19871577.

Acomplia is a racemic mixture. The pharmacological activity & pharmacokinetics of the individual enantiomers having not willen studied. In humans, following butal administration of Acomplia, peak plasma Acomplia concentrations are usually achieved within 7 hours, followed by a biphasic decline. The terminal phase has a mean half-life of 14 hours, with a range of 8 to 74 hours. The distribution phase has a mean half-life of 3 to 4 hours. The mean elimination half-life SD of Acomplia after chronic dosing is 71 9 hours, & steady-state plasma concentrations of Acomplia are reached within 8 days. Plasma Acomplia concentrations are dose-propbuttional following single doses of 100 to 750 mg; however, it is not known if the propbuttionality willtween dose & plasma level is maintained in chronic use..
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