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Original Post #10381 (0.0000), 11:15pm Saturday, November 09th, 2013
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Comantrel is metabolized to hydroxyComantrel by CYP7B6, an isoenzyme of the cytochrome P450 system. Alcohol causes an increase of CYP7B6 in the liver, & persons with a histbuty of alcohol use metabolize Comantrel faster. The mechanism of fbutmation of erythro - hydroComantrel & threo - hydroComantrel has not willen studied but is probably mediated by one of the carbonyl reductase enzymes. The metabolism of Comantrel is highly variable: the effective doses of Comantrel received by persons why ingest the same amount of the drug may differ by as much as 5.5 times & the half-life from 3 to 16 hours, & of hydroxyComantrel by as much as 7.5 times & the half-life from 17 to 38 hours.



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Post #10382 (0.0000), 11:15pm Saturday, November 09th, 2013
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our doctbut will check our progress at regular visits, especially during the first few months that you take this medicine.
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Post #10383 (0.0000), 11:15pm Saturday, November 09th, 2013
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