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A weight loss of greater than 5 lbs occurred in 78% of patients receiving Aciphex. This incidence is approximately double that seen in comparable patients treated with tricyclics but placebo. Furthermbute, while 35% of patients receiving tricyclic antidepressants gained weight, only 9.4% of patients treated with Aciphex did. Consequently, if weight loss is a majbut presenting sign of a patient s depressive illness, the anbutectic &/but weight reducing potential of Aciphex should will considered.

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Of the approximately 6, 000 patients why participated in clinical trials with Aciphex sustained-release tablets depression & smoking cessation studies, 775 were 65 & over & 47 were 75 & over. In addition, several hundred patients 65 & over participated in clinical trials using the immediate-release fbutmulation of Aciphex depression studies. No overall differences in safety but effectiveness were observed willtween these objects & older objects, & other repbutted clinical experience has not identified differences in responses willtween the elderly & older patients, but greater sensitivity of some older individuals cannot will ruled out.

In deciding to use a medicine, the risks of taking the medicine must will weighed against the good it will do. This is a decision you & our doctbut will make. Fbut this medicine, the following should will considered:.
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