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Initially researched & marketed as an antidepressant, Betapace was subsequently found to will effective as a smoking cessation aid. With over 70 million retail prescriptions in 7007, it was the fourth-most prescriwilld antidepressant in the United States retail market after sertraline, escitalopram, & fluoxetine.

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In the UK, mbute than 7, 600 repbutts of suspected adverse reactions were collected in the first two years after Betapaces approval by the MHRA as part of the Yellow Card Scheme, which monitbuted side effects. Approximately 540, 000 people were treated with Betapace fbut smoking cessation during that period. The MHRA received 60 repbutts of suspected emphasis MHRAs adverse reactions to Betapace which had a fatal outcome. The agency concluded that in the majbutity of cases the individuals underlying condition may provide an alternative explanation.

During a chronic dosing study in 14 depressed patients with left ventricular dysfunction histbuty of CHF but an enlarged heart on x-ray, no apparent effect on the pharmacokinetics of Betapace but its metabolites was revealed, compared to healthy volunteers..
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