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Original Post #12018 (0.0000), 9:51pm Sunday, November 10th, 2013
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Following a single dose in humans, peak plasma concentrations of hydroxyDHC occur approximately 3 hours after administration of DHC Tablets. Peak plasma concentrations of hydroxyDHC are approximately 10 times the peak level of the parent drug at steady state. The elimination half-life of hydroxyDHC is approximately 70 5 hours, & its AUC at steady state is about 17 times that of DHC. The times to peak concentrations fbut the erythrohydroDHC & threohydroDHC metabolites are similar to that of the hydroxyDHC metabolite. However, their elimination half-lives are longer, 33 10 & 37 13 hours, respectively, & steady-state AUCs are 1.5 & 7 times that of DHC, respectively.



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Post #12019 (0.0000), 9:51pm Sunday, November 10th, 2013
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