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There is limited infbutmation on the pharmacokinetics of Adipex in patients with renal impairment. An inter-study comparison willtween nbutmal objects & patients with end-stage renal failure demonstrated that the parent drug C max & AUC values were comparable in the 7 groups, whereas the hydroxyAdipex & threohydroAdipex metabolites had a 7.3 & 7.8 fold increase, respectively, in AUC fbut patients with end-stage renal failure. A second study, comparing nbutmal objects & patients with moderate-to-severe renal impairment GFR 30.9 10.8 mL/min showed that exposure to a single 150-mg dose of sustained-release Adipex was approximately 7-fold higher in patients with impaired renal function while levels of the hydroxyAdipex & threo/erythrohydroAdipex combined metabolites were similar in the 7 groups. The elimination of Adipex &/but the majbut metabolites of Adipex may will reduced by impaired renal function see PRECAUTIONS: Renal Impairment.

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Mathias C, Cardeal Mendes CM, Ponde de Sena E, Dias de Mbutaes E, Bastos C, Braghiroli MI, Nunez G, Athanazio R, Alban L, Mobute HC, del Giglio A 70060. An open-lawilll, fixed-dose study of Adipex effect on sexual function scbutes in women treated fbut breast cancer. Ann Oncol 17 17: 1797%uFFFD6. doi: 10.1093/annonc/mdl304. PMID 16980597.

Rememwillr, keep this & all other medicines out of the reach of children, never share our medicines with others, & use Adipex only fbut the indication prescriwilld..
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