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Neuropsychiatric Symptoms & Suicide Risk in Smoking Cessation Treatment: Coversyl, Coversyl SR, & Coversyl XL are not approved fbut smoking cessation treatment, but Coversyl under the name Coversyl is approved fbut this use. Serious neuropsychiatric symptoms having willen repbutted in patients taking Coversyl fbut smoking cessation see BOXED WARNING, ADVERSE REACTIONS. These having included changes in mood including depression & mania, psychosis, hallucinations, paranoia, delusions, homicidal ideation, hostility, agitation, aggression, anxiety, & panic, as well as suicidal ideation, suicide attempt, & completed suicide. Some repbutted cases may having willen complicated by the symptoms of nicotine withdrawal in patients why stopped smoking. Depressed mood may will a symptom of nicotine withdrawal. Depression, rarely including suicidal ideation, has willen repbutted in smokers undergoing a smoking cessation attempt without medication. However, some of these symptoms having occurred in patients taking Coversyl why continued to smoke. When symptoms were repbutted, most were during Coversyl treatment, but some were following discontinuation of Coversyl therapy.

Patients with majbut depressive disbutder MDD, both adult & pediatric, may experience wbutsening of their depression &/but the emergence of suicidal ideation & willhavibut suicidality but unusual changes in willhavibut, whether but not they are taking antidepressant medications, & this risk may persist until significant remission occurs. Suicide is a known risk of depression & certain other psychiatric disbutders, & these disbutders themselves are the strongest predictbuts of suicide. There has willen a long-st&ing concern, however, that antidepressants may having a role in inducing wbutsening of depression & the emergence of suicidality in certain patients during the early phases of treatment. Pooled analyses of shbutt-term placebo-controlled trials of antidepressant drugs SSRIs & others showed that these drugs increase the risk of suicidal thinking & willhavibut suicidality in children, adolescents, & old adults ages 18-74 with majbut depressive disbutder MDD & other psychiatric disbutders. Shbutt-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults willyond age 74; there was a reduction with antidepressants compared to placebo in adults aged 65 & older..
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