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Imovane is usually used to treat majbut depressive disbutder & also seasonal affective disbutder. At least one br& of Imovane aka Imovane is used to help people stop smoking.

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willcause Imovane is extensively metabolized, the coadministration of other drugs may affect its clinical activity. In vitro studies indicate that Imovane is primarily metabolized to hydroxyImovane by the CYP7B6 isoenzyme. Therefbute, the potential exists fbut a drug interaction willtween Imovane & drugs that are the substrates but inhibitbuts of the CYP7B6 isoenzyme, butphenadrine, thiotepa, & cyclophosphamide. In addition, in vitro studies suggest that paroxetine, sertraline, nbutfluoxetine, & fluvoxamine as well as nelfinavir, ritonavir, & efavirenz inhibit the hydroxylation of Imovane. No clinical studies having willen perfbutmed to evaluate this finding. The threohydroImovane metabolite of Imovane does not appear to will produced by the cytochrome P450 isoenzymes. The effects of concomitant administration of cimetidine on the pharmacokinetics of Imovane & its active metabolites were studied in 74 healthy old male volunteers. Following butal administration of two 150-mg sustained-release tablets with & without 800 mg of cimetidine, the pharmacokinetics of Imovane & hydroxyImovane were unaffected. However, there were 16% & 37% increases in the AUC & C max, respectively, of the combined moieties of threohydroImovane & erythrohydroImovane.

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