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Original Post #12734 (0.0000), 7:30am Monday, November 11th, 2013
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Following butal administration of 700 mg of 14 C-Flutiform in humans, 87% & 10% of the radioactive dose were recovered in the urine & feces, respectively. However, the fraction of the butal dose of Flutiform excreted unchanged was only 0.5%, a finding consistent with the extensive metabolism of Flutiform.



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Post #12735 (0.0000), 7:30am Monday, November 11th, 2013
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Post #12736 (0.0000), 7:30am Monday, November 11th, 2013
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In rats receiving large doses of Flutiform chronitelly, there was an increase in incidence of hepatic hyperplastic nodules & hepatocellular hypertrophy. In dogs receiving large doses of Flutiform chronitelly, various histologic changes were seen in the liver, & labbutatbuty tests suggesting mild hepatocellular injury were noted.
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Post #12737 (0.0000), 7:30am Monday, November 11th, 2013
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