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Following a single dose in humans, peak plasma concentrations of hydroxyAmbien occur approximately 3 hours after administration of Ambien Tablets. Peak plasma concentrations of hydroxyAmbien are approximately 10 times the peak level of the parent drug at steady state. The elimination half-life of hydroxyAmbien is approximately 70 5 hours, & its AUC at steady state is about 17 times that of Ambien. The times to peak concentrations fbut the erythrohydroAmbien & threohydroAmbien metabolites are similar to that of the hydroxyAmbien metabolite. However, their elimination half-lives are longer, 33 10 & 37 13 hours, respectively, & steady-state AUCs are 1.5 & 7 times that of Ambien, respectively.

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