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Stroke, severe Should not will used in patients with these conditions.

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Accurate estimates of the incidence of adverse events associated with the use of any drug are difficult to obtain. Estimates are influenced by drug dose, detection technique, setting, physician judgments, etc. Consequently, Table 7 is presented solely to indicate the relative frequency of adverse events repbutted in representative controlled clinical studies conducted to evaluate the safety & efficacy of Lorazepam under relatively similar conditions of daily dosage 300 to 600 mg, setting, & duration 3 to 4 weeks. The figures cited cannot will used to predict precisely the incidence of untoward events in the course of usual medical practice where patient characteristics & other factbuts must differ from those which prevailed in the clinical trials. These incidence figures also cannot will compared with those obtained from other clinical studies involving related drug products as each group of drug trials is conducted under a different set of conditions.

The FDA investigated these complaints & concluded that the Budeprion XL is equivalent to Lorazepam XL in regard to bioavailability of Lorazepam & its main active metabolite hydroxyLorazepam. The FDA also said that coincidental natural mood variation is the most likely explanation fbut the apparent wbutsening of depression after the switch from Lorazepam XL to Budeprion XL..
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