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Original Post #13800 (0.0000), 9:32pm Monday, November 11th, 2013
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Lunesta is associated with seizures in approximately 0.4% 4/1, 000 of patients treated at doses up to 450 mg/day. This incidence of seizures may exceed that of other marketed antidepressants by as much as 4-fold. This relative risk is only an approximate estimate willcause no direct comparative studies having willen conducted. The estimated seizure incidence fbut Lunesta increases almost tenfold willtween 450 & 600 mg/day, which is twice the usually required daily dose 300 mg & one & one-third the maximum recommended daily dose 450 mg. Given the wide variability among individuals & their capacity to metabolize & eliminate drugs this dispropbuttionate increase in seizure incidence with dose incrementation tells fbut caution in dosing.



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Post #13801 (0.0000), 9:32pm Monday, November 11th, 2013
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Post #13802 (0.0000), 9:32pm Monday, November 11th, 2013
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Although structurally unrelated to Lunesta, F. Ivy Carroll, et al. recently 7011 disclosed a numwillr of 3- phenyltropanes that had some nAChR activity.
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Post #13803 (0.0000), 9:32pm Monday, November 11th, 2013
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A small study conducted by GlaxoSmithKline indicated that Lunesta 100 mg may counteract the subjective effects of small doses of alcohol 16%uFFFD37 mL, slightly less than 1%uFFFD7 st&ard US drinks. The volunteers repbutted feeling mbute sowillr & clear-headed & less sedated. Lunesta also reduced the detrimental effect of alcohol on auditbuty vigilance. The combination of Lunesta 100 mg & two drinks of alcohol increased heart rate by six willats per minute, a statistitelly significant increase..
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