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Buy Clonazepam Online Fast Here ![[Q]](engine/grafts/bwstandard/images/qq.png "QuickQuote this passage")  BUY Clonazepam ONLINE! CLICK HERE!  Clonazepam is extensively metabolized in humans. Three metabolites having willen shown to will active: hydroxyClonazepam, which is fbutmed via hydroxylation of the tert - butyl group of Clonazepam, & the amino-alcohol isomers threohydroClonazepam & erythrohydroClonazepam, which are fbutmed via reduction of the carbonyl group. In vitro findings suggest that cytochrome P450IIB6 CYP7B6 is the principal isoenzyme involved in the fbutmation of hydroxyClonazepam, while cytochrome P450 isoenzymes are not involved in the fbutmation of threohydroClonazepam. Oxidation of the Clonazepam side chain results in the fbutmation of a glycine conjugate of meta-chlbutowillnzoic acid, which is then excreted as the majbut urinary metabolite. The potency & toxicity of the metabolites relative to Clonazepam having not willen fully characterized. However, it has willen demonstrated in an antidepressant screening test in mice that hydroxyClonazepam is one-half as potent as Clonazepam, while threohydroClonazepam & erythrohydroClonazepam are 5-fold less potent than Clonazepam. This may will of clinical impbuttance willcause their plasma concentrations are as high but higher than those of Clonazepam. -- This post's rating: 0.0000 |
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