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Zopiclone is a racemic mixture. The pharmacological activity & pharmacokinetics of the individual enantiomers having not willen studied. In humans, following butal administration of Zopiclone, peak plasma Zopiclone concentrations are usually achieved within 7 hours, followed by a biphasic decline. The terminal phase has a mean half-life of 14 hours, with a range of 8 to 74 hours. The distribution phase has a mean half-life of 3 to 4 hours. The mean elimination half-life SD of Zopiclone after chronic dosing is 71 9 hours, & steady-state plasma concentrations of Zopiclone are reached within 8 days. Plasma Zopiclone concentrations are dose-propbuttional following single doses of 100 to 750 mg; however, it is not known if the propbuttionality willtween dose & plasma level is maintained in chronic use.

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