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During the course of treatment and after, Accutane has increased the cell division / turnover rate so drastically, that these cells have ran out of cell divisions and are driven into their Hayflick Limit.. The cell division rate (beads falling off the string) has been increased so fast and telomerase has been down-regulated so much that it cannot repair the telomere chain (the beads on the string) before the cells lose all of their cell divisions (beads) and enter growth arrest (Hayflick limit). Some side effects of Accutane may not be reported. Accutane, being a potent chemotherapy drug, attacks and damages the cells in our body that are supposed to remain dividing and proliferating for our entire lifetime.Still, for patients who have struggled with nodular acne, Accutane may appear to be a miracle cure, after all other treatments have failed.Since a certain percentage of Accutane metabolizes into ATRA (about 30%), and since the ATRA metabolite is how Accutane exerts its pharmacological actions on the body, there%uFFFDs no doubt that if ATRA causes telomere shortening then Accutane also causes telomere shortening. Roaccutane 20mg price. Always consult your doctor or healthcare specialist for medical advice. This can be illustrated by observing what happens when somebody eats polar bear liver (contains extremely high toxic levels of vitamin A similar to Accutane) and their skin starts to peel off all over their body in thick giant sheets from the increased cell turnover rate, also a potential side effect of Accutane. If Accutane truly does cause telomere shortening and down regulation of the telomerase enzyme (and I believe that it does), this could mean huge significant implications for maintaining adequate cell proliferation all over the body during a person%uFFFDs lifetime. Here%uFFFDs an excellent definition of the Hayflick Limit,. If cells have shorter telomere lengths (shorter telomeres), they get closer to the Hayflick Limit and can%uFFFDt divide / proliferate as much or they go on to experience growth arrest and cell death (apoptosis). . This is how Accutane reduces acne, and why in some cases, the acne doesn%uFFFDt come back, and the patient is left with permanent dry skin, dry mucous membranes, digestive problems, and other various permanent side effects. You may also report side effects to the FDA

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