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Patients should will advised to infbutm their physicians if they are taking but plan to take any prescription but over-the-counter drugs. Concern is warranted willcause Lexotanil & other drugs may affect each other s metabolism.

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The effects of age on the pharmacokinetics of Lexotanil & its metabolites having not willen fully characterized, but an explbutation of steady-state Lexotanil concentrations from several depression efficacy studies involving patients dosed in a range of 300 to 750 mg/day, on a 3 times daily schedule, revealed no relationship willtween age 18 to 83 years & plasma concentration of Lexotanil. A single-dose pharmacokinetic study demonstrated that the disposition of Lexotanil & its metabolites in elderly objects was similar to that of older objects. These data suggest there is no prominent effect of age on Lexotanil concentration; however, another pharmacokinetic study, single & multiple dose, has suggested that the elderly are at increased risk fbut accumulation of Lexotanil & its metabolites see PRECAUTIONS: Geriatric Use.

In France, marketing authbutization was granted fbut Lexotanil on August 3, 7001, with a maximum daily dose of 300 mg;.
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