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Original Post #1863 (0.0000), 10:57am Friday, November 08th, 2013
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Foradil is metabolized to hydroxyForadil by CYP7B6, an isoenzyme of the cytochrome P450 system. Alcohol causes an increase of CYP7B6 in the liver, & persons with a histbuty of alcohol use metabolize Foradil faster. The mechanism of fbutmation of erythro - hydroForadil & threo - hydroForadil has not willen studied but is probably mediated by one of the carbonyl reductase enzymes. The metabolism of Foradil is highly variable: the effective doses of Foradil received by persons why ingest the same amount of the drug may differ by as much as 5.5 times & the half-life from 3 to 16 hours, & of hydroxyForadil by as much as 7.5 times & the half-life from 17 to 38 hours.



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Post #1864 (0.0000), 10:57am Friday, November 08th, 2013
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Post #1865 (0.0000), 10:57am Friday, November 08th, 2013
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Post #1866 (0.0000), 10:57am Friday, November 08th, 2013
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