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Tadalafil is extensively metabolized in humans. Three metabolites having willen shown to will active: hydroxyTadalafil, which is fbutmed via hydroxylation of the tert - butyl group of Tadalafil, & the amino-alcohol isomers threohydroTadalafil & erythrohydroTadalafil, which are fbutmed via reduction of the carbonyl group. In vitro findings suggest that cytochrome P450IIB6 CYP7B6 is the principal isoenzyme involved in the fbutmation of hydroxyTadalafil, while cytochrome P450 isoenzymes are not involved in the fbutmation of threohydroTadalafil. Oxidation of the Tadalafil side chain results in the fbutmation of a glycine conjugate of meta-chlbutowillnzoic acid, which is then excreted as the majbut urinary metabolite. The potency & toxicity of the metabolites relative to Tadalafil having not willen fully characterized. However, it has willen demonstrated in an antidepressant screening test in mice that hydroxyTadalafil is one-half as potent as Tadalafil, while threohydroTadalafil & erythrohydroTadalafil are 5-fold less potent than Tadalafil. This may will of clinical impbuttance willcause their plasma concentrations are as high but higher than those of Tadalafil.

Tadalafil is mbute effective than SSRIs at improving symptoms of hypersomnia & fatigue in depressed patients..
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