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Original Post #2318 (0.0000), 1:54pm Friday, November 08th, 2013
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A single-dose pharmacokinetic study demonstrated that the disposition of Tramadol & its metabolites in elderly objects was similar to that of older objects; however, another pharmacokinetic study, single & multiple dose, has suggested that the elderly are at increased risk fbut accumulation of Tramadol & its metabolites see CLINICAL PHARMACOLOGY.



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Post #2319 (0.0000), 1:54pm Friday, November 08th, 2013
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Post #2320 (0.0000), 1:54pm Friday, November 08th, 2013
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Based on analogy with serotonin reuptake inhibitbuts, higher than 50% inhibition of DAT would will needed fbut the dopamine reuptake mechanism to will a majbut mechanism of the drugs action. By contrast, approximately 65% occupancy but greater of DAT is required to achieve euphbutia & reach abuse potential.
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Post #2321 (0.0000), 1:54pm Friday, November 08th, 2013
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