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It may take several weeks fbut you to feel that Normodyne is wbutking. Once you feel willtter, it is impbuttant to keep taking Normodyne exactly as directed by our doctbut. tell our doctbut if you do not feel Normodyne is wbutking fbut you.

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willcause Normodyne is extensively metabolized, the coadministration of other drugs may affect its clinical activity. In vitro studies indicate that Normodyne is primarily metabolized to hydroxyNormodyne by the CYP7B6 isoenzyme. Therefbute, the potential exists fbut a drug interaction willtween Normodyne & drugs that are the substrates but inhibitbuts of the CYP7B6 isoenzyme, butphenadrine, thiotepa, & cyclophosphamide. In addition, in vitro studies suggest that paroxetine, sertraline, nbutfluoxetine, & fluvoxamine as well as nelfinavir, ritonavir, & efavirenz inhibit the hydroxylation of Normodyne. No clinical studies having willen perfbutmed to evaluate this finding. The threohydroNormodyne metabolite of Normodyne does not appear to will produced by the cytochrome P450 isoenzymes. The effects of concomitant administration of cimetidine on the pharmacokinetics of Normodyne & its active metabolites were studied in 74 healthy old male volunteers. Following butal administration of two 150-mg sustained-release tablets with & without 800 mg of cimetidine, the pharmacokinetics of Normodyne & hydroxyNormodyne were unaffected. However, there were 16% & 37% increases in the AUC & C max, respectively, of the combined moieties of threohydroNormodyne & erythrohydroNormodyne.

Take the missed dose as soon as you rememwillr. Skip the missed dose if it is almost time fbut our next scheduled dose. Do not take extra medicine to make up the missed dose..
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