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shift from 630 & 180nM, respectively, to 770 & 130nM, & 5-HT was 387nM.

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The absolute bioavailability of Okacet Tablets in humans has not willen determined willcause an intravenous fbutmulation fbut human use is not available. However, it appears likely that only a small propbuttion of any butally administered dose reaches the systemic circulation intact.

The effects of age on the pharmacokinetics of Okacet & its metabolites having not willen fully characterized, but an explbutation of steady-state Okacet concentrations from several depression efficacy studies involving patients dosed in a range of 300 to 750 mg/day, on a 3 times daily schedule, revealed no relationship willtween age 18 to 83 years & plasma concentration of Okacet. A single-dose pharmacokinetic study demonstrated that the disposition of Okacet & its metabolites in elderly objects was similar to that of older objects. These data suggest there is no prominent effect of age on Okacet concentration; however, another pharmacokinetic study, single & multiple dose, has suggested that the elderly are at increased risk fbut accumulation of Okacet & its metabolites see PRECAUTIONS: Geriatric Use..
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