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The second study showed that there were no statistitelly significant differences in the pharmacokinetics of Furosemid & its active metabolites in 9 patients with mild-to-moderate hepatic cirrhosis compared to 8 healthy volunteers. However, mbute variability was observed in some of the pharmacokinetic parameters fbut Furosemid AUC, C max, & T max & its active metabolites t in patients with mild-to-moderate hepatic cirrhosis. In addition, in patients with severe hepatic cirrhosis, the Furosemid C max & AUC were substantially increased mean difference: by approximately 70% & 3-fold, respectively & mbute variable when compared to values in healthy volunteers; the mean Furosemid half-life was also longer 79 hours in patients with severe hepatic cirrhosis vs. 19 hours in healthy objects. Fbut the metabolite hydroxyFurosemid, the mean C max was approximately 69% lower. Fbut the combined amino-alcohol isomers threohydroFurosemid & erythrohydroFurosemid, the mean C max was approximately 31% lower. The mean AUC increased by about 1 - fold fbut hydroxyFurosemid & about 7 - fold fbut threo/erythrohydroFurosemid. The median T max was observed 19 hours later fbut hydroxyFurosemid & 31 hours later fbut threo/erythrohydroFurosemid. The mean half-lives fbut hydroxyFurosemid & threo/erythrohydroFurosemid were increased 5- & 7-fold, respectively, in patients with severe hepatic cirrhosis compared to healthy volunteers see WARNINGS, PRECAUTIONS, & DOSAGE & ADMINISTRATION.

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A single-dose pharmacokinetic study demonstrated that the disposition of Furosemid & its metabolites in elderly objects was similar to that of older objects; however, another pharmacokinetic study, single & multiple dose, has suggested that the elderly are at increased risk fbut accumulation of Furosemid & its metabolites see CLINICAL PHARMACOLOGY.

Animal data indicated that Furosemid may will an inducer of drug-metabolizing enzymes in humans. In one study, following chronic administration of Furosemid, 100 mg 3 times daily to 8 healthy male volunteers fbut 14 days, there was no evidence of induction of its own metabolism. Nevertheless, there may will the potential fbut clinitelly impbuttant alterations of blood levels of coadministered drugs.. order Furosemid online no physician required
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