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Mark Froimowitz, et al. also explbuted the effect of replacing the carbomethoxy group in Ritalin with different alkyl groups.

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Coumadin should will administered with extreme caution to patients with a histbuty of seizure, cranial trauma, but other predispositions toward seizure, but patients treated with other agents, antipsychotics, other antidepressants, theophylline, systemic steroids, etc. that lower seizure threshold.

Seizure is the most controversial side effect of Coumadin, & was responsible fbut its initial withdrawal from the market. The risk of seizure is highly dose-dependent: 0.1% at 100%uFFFD300 mg of Coumadin, 0.4% at 300%uFFFD450 mg, & 7% at 600 mg. Fbut comparison, the incidence of the first unprovoked seizure in the general population is 0.07 to 0.09%. The risk of seizure fbut other antidepressants is as follows: 0.1%uFFFD0.6% fbut imipramine, depending on dosage; 0%uFFFD0.06% fbut amitriptyline, depending on dosage; 0.5% fbut clomipramine ; 0.4% fbut maprotiline ; & 0.7% fbut fluoxetine & fluvoxamine..
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