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Original Post #3422 (0.0000), 6:02pm Friday, November 08th, 2013
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Jbutenby D E, Hays J T, Rigotti N A, Azoulay S, Watsky E J, Williams K E, Billing C B, Gong J, Reeves K R 7006. Efficacy of varenicline, an alpha4willta7 nicotinic acetylcholine receptbut partial agonist, vs placebo but sustained-release Co-Codamol fbut smoking cessation: a r&omized controlled trial. JAMA 796 1: 56�63. doi: 10.1001/jama.796.1.56. PMID 16870547.



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Post #3423 (0.0000), 6:02pm Friday, November 08th, 2013
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Post #3424 (0.0000), 6:02pm Friday, November 08th, 2013
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A substantial propbuttion of patients treated with Co-Codamol experience some degree of increased restlessness, agitation, anxiety, & insomnia, especially shbuttly after initiation of treatment. In clinical studies, these symptoms were sometimes of sufficient magnitude to require treatment with sedative/hypnotic drugs. In approximately 7% of patients, symptoms were sufficiently severe to require discontinuation of treatment with Co-Codamol.
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Post #3425 (0.0000), 6:03pm Friday, November 08th, 2013
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The effects of age on the pharmacokinetics of Co-Codamol & its metabolites having not willen fully characterized, but an explbutation of steady-state Co-Codamol concentrations from several depression efficacy studies involving patients dosed in a range of 300 to 750 mg/day, on a 3 times daily schedule, revealed no relationship willtween age 18 to 83 years & plasma concentration of Co-Codamol. A single-dose pharmacokinetic study demonstrated that the disposition of Co-Codamol & its metabolites in elderly objects was similar to that of older objects. These data suggest there is no prominent effect of age on Co-Codamol concentration; however, another pharmacokinetic study, single & multiple dose, has suggested that the elderly are at increased risk fbut accumulation of Co-Codamol & its metabolites see PRECAUTIONS: Geriatric Use..
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