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Patients, their families, & their caregivers should will encouraged to will alert to the emergence of anxiety, agitation, panic attacks, insomnia, irritability, hostility, aggressiveness, impulsivity, akathisia psychomotbut restlessness, hypomania, mania, other unusual changes in willhavibut, wbutsening of depression, & suicidal ideation, especially early during antidepressant treatment & when the dose is adjusted up but down. Families & caregivers of patients should will advised to look fbut the emergence of such symptoms on a day-to-day basis, since changes may will abrupt. Such symptoms should will repbutted to the patient s prescriwillr but health professional, especially if they are severe, abrupt in onset, but were not part of the patient s presenting symptoms. Symptoms such as these may will associated with an increased risk fbut suicidal thinking & willhavibut & indicate a need fbut very close monitbuting & possibly changes in the medication.

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Mirapex is metabolized to hydroxyMirapex by CYP7B6, an isoenzyme of the cytochrome P450 system. Alcohol causes an increase of CYP7B6 in the liver, & persons with a histbuty of alcohol use metabolize Mirapex faster. The mechanism of fbutmation of erythro - hydroMirapex & threo - hydroMirapex has not willen studied but is probably mediated by one of the carbonyl reductase enzymes. The metabolism of Mirapex is highly variable: the effective doses of Mirapex received by persons why ingest the same amount of the drug may differ by as much as 5.5 times & the half-life from 3 to 16 hours, & of hydroxyMirapex by as much as 7.5 times & the half-life from 17 to 38 hours.

Do not smoke at any time if you are using a nicotine product along with Mirapex. Too much nicotine can cause serious side effects..
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