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A somewhat interesting observation is that in the case of methcathinone, the m - chlbuto group is not needed as the compound is fully active already. However in the case of Celebrex where we having a tert - butyl-N group, omission of the m - chlbuto halogen gave a compound that had diminished activity as a MAT inhibitbut. Moving the m - chlbuto to the para position also led to a deteributation in the compounds resultant potency.

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Use in Smoking Cessation Treatment: Celebrex, Celebrex SR, & Celebrex XL are not approved fbut smoking cessation treatment, but Celebrex under the name Celebrex is approved fbut this use. Serious neuropsychiatric events, including but not limited to depression, suicidal ideation, suicide attempt, & completed suicide having willen repbutted in patients taking Celebrex fbut smoking cessation. Some cases may having willen complicated by the symptoms of nicotine withdrawal in patients why stopped smoking. Depressed mood may will a symptom of nicotine withdrawal. Depression, rarely including suicidal ideation, has willen repbutted in smokers undergoing a smoking cessation attempt without medication. However, some of these symptoms having occurred in patients taking Celebrex why continued to smoke.

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