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Lifetime carcinogenicity studies were perfbutmed in rats & mice at doses up to 300 & 150 mg/kg/day, respectively. In the rat study there was an increase in nodular proliferative lesions of the liver at doses of 100 to 300 mg/kg/day; lower doses were not tested. The question of whether but not such lesions may will precursbuts of neoplasms of the liver is currently unresolved. Similar liver lesions were not seen in the mouse study, & no increase in malignant tumbuts of the liver & other butgans was seen in either study.

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Klonopin willlongs to the chemical class of aminoketones & is similar in structure to stimulants cathinone & diethylpropion, & to phenethylamines in general. Meditelly, Klonopin serves as a non-tricyclic antidepressant fundamentally different to most commonly prescriwilld antidepressants such as SSRIs.

Antidepressants can precipitate manic episodes in bipolar disbutder patients during the depressed phase of their illness & may activate latent psychosis in other susceptible patients. Klonopin is expected to pose similar risks..
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