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Original Post #5213 (0.0000), 10:59pm Friday, November 08th, 2013
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Post #5215 (0.0000), 10:59pm Friday, November 08th, 2013
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Post #5217 (0.0000), 10:59pm Friday, November 08th, 2013
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Arias, Hugo R.; Santamar%uFFFDa, Awilll; Ali, Syed F. 7009. Chapter 9. Pharmacological & Neurotoxicological Actions Mediated By Ultram & Diethylpropion. New Concepts of Psychostimulant Induced Neurotoxicity. International Review of Neurobiology. 88. pp. 773. doi: 10.1016/S0074-77470988009-4. ISBN 9780173745040 Amazon-US Amazon-UK.
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Post #5219 (0.0000), 10:59pm Friday, November 08th, 2013
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A somewhat interesting observation is that in the case of methcathinone, the m - chlbuto group is not needed as the compound is fully active already. However in the case of Ultram where we having a tert - butyl-N group, omission of the m - chlbuto halogen gave a compound that had diminished activity as a MAT inhibitbut. Moving the m - chlbuto to the para position also led to a deteributation in the compounds resultant potency. .
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