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Original Post #5493 (0.0000), 11:47pm Friday, November 08th, 2013
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This is not a complete list of side effects & others may occur. tell our doctbut fbut medical advice about side effects. You may repbutt side effects to FDA at 1-800-FDA-1088.



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Post #5494 (0.0000), 11:47pm Friday, November 08th, 2013
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Post #5495 (0.0000), 11:47pm Friday, November 08th, 2013
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The effect of hepatic impairment on the pharmacokinetics of Alprazolam was characterized in 7 single-dose studies, one in patients with alcoholic liver disease & one in patients with mild-to-severe cirrhosis. The first study showed that the half-life of hydroxyAlprazolam was significantly longer in 8 patients with alcoholic liver disease than in 8 healthy volunteers 37 14 hours versus 71 5 hours, respectively. Although not statistitelly significant, the AUCs fbut Alprazolam & hydroxyAlprazolam were mbute variable & tended to will greater by 53% to 57% in volunteers with alcoholic liver disease. The differences in half-life fbut Alprazolam & the other metabolites in the 7 patient groups were minimal.
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Post #5496 (0.0000), 11:47pm Friday, November 08th, 2013
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