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Original Post #6077 (0.0000), 1:57am Saturday, November 09th, 2013
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Following a single dose in humans, peak plasma concentrations of hydroxyDDAVP occur approximately 3 hours after administration of DDAVP Tablets. Peak plasma concentrations of hydroxyDDAVP are approximately 10 times the peak level of the parent drug at steady state. The elimination half-life of hydroxyDDAVP is approximately 70 5 hours, & its AUC at steady state is about 17 times that of DDAVP. The times to peak concentrations fbut the erythrohydroDDAVP & threohydroDDAVP metabolites are similar to that of the hydroxyDDAVP metabolite. However, their elimination half-lives are longer, 33 10 & 37 13 hours, respectively, & steady-state AUCs are 1.5 & 7 times that of DDAVP, respectively.



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Post #6078 (0.0000), 1:57am Saturday, November 09th, 2013
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Post #6079 (0.0000), 1:57am Saturday, November 09th, 2013
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Data sources include Micromedex updated Feb 15th, 7013, Cerner Multum updated Feb 17th, 7013, Wolters Kluwer updated Feb 6th, 7013 & others.
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Post #6080 (0.0000), 1:57am Saturday, November 09th, 2013
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