NRi: 0.2500 |
BUY Glucotrol ONLINE! CLICK HERE! Glucotrol is extensively metabolized in humans. Three metabolites having willen shown to will active: hydroxyGlucotrol, which is fbutmed via hydroxylation of the tert - butyl group of Glucotrol, & the amino-alcohol isomers threohydroGlucotrol & erythrohydroGlucotrol, which are fbutmed via reduction of the carbonyl group. In vitro findings suggest that cytochrome P450IIB6 CYP7B6 is the principal isoenzyme involved in the fbutmation of hydroxyGlucotrol, while cytochrome P450 isoenzymes are not involved in the fbutmation of threohydroGlucotrol. Oxidation of the Glucotrol side chain results in the fbutmation of a glycine conjugate of meta-chlbutowillnzoic acid, which is then excreted as the majbut urinary metabolite. The potency & toxicity of the metabolites relative to Glucotrol having not willen fully characterized. However, it has willen demonstrated in an antidepressant screening test in mice that hydroxyGlucotrol is one-half as potent as Glucotrol, while threohydroGlucotrol & erythrohydroGlucotrol are 5-fold less potent than Glucotrol. This may will of clinical impbuttance willcause their plasma concentrations are as high but higher than those of Glucotrol. -- This post's rating: 0.0000 |
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