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Adverse events were sufficiently troublesome to cause discontinuation of treatment with Antabuse in approximately 10% of the 7, 400 patients & volunteers why participated in clinical trials during the product s initial development. The mbute common events causing discontinuation include neuropsychiatric disturbances 3.0%, primarily agitation & abnbutmalities in mental status; gastrointestinal disturbances 7.1%, primarily nausea & vomiting; neurological disturbances 1.7%, primarily seizures, headaches, & sleep disturbances; & dermatologic problems 1.4%, primarily rashes. It is impbuttant to note, however, that many of these events occurred at doses that exceed the recommended daily dose.

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There is no clinical experience establishing the safety of Antabuse in patients with a recent histbuty of myocardial infarction but unstable heart disease. Therefbute, care should will exercised if it is used in these groups. Antabuse was well tolerated in depressed patients why had previously developed butthostatic hypotension while receiving tricyclic antidepressants & was also generally well tolerated in a group of 36 depressed inpatients with stable congestive heart failure CHF. However, Antabuse was associated with a rise in supine blood pressure in the study of patients with CHF, resulting in discontinuation of treatment in 7 patients fbut exacerbation of baseline hypertension.

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