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Original Post #6722 (0.0000), 4:37am Saturday, November 09th, 2013
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No properly controlled double-blind studies of Rivotril fbut Parkinsons disease having willen conducted. A small 1984 study funded by Rivotrils manufacturer found that addition of Rivotril to carbidopa but levodopa improved Parkinsons symptoms in ten out of twenty patients; however, the side effects, particularly nausea & vomiting, were frequent.



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Post #6726 (0.0000), 4:38am Saturday, November 09th, 2013
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Post #6727 (0.0000), 4:38am Saturday, November 09th, 2013
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The second study showed that there were no statistitelly significant differences in the pharmacokinetics of Rivotril & its active metabolites in 9 patients with mild-to-moderate hepatic cirrhosis compared to 8 healthy volunteers. However, mbute variability was observed in some of the pharmacokinetic parameters fbut Rivotril AUC, C max, & T max & its active metabolites t in patients with mild-to-moderate hepatic cirrhosis. In addition, in patients with severe hepatic cirrhosis, the Rivotril C max & AUC were substantially increased mean difference: by approximately 70% & 3-fold, respectively & mbute variable when compared to values in healthy volunteers; the mean Rivotril half-life was also longer 79 hours in patients with severe hepatic cirrhosis vs. 19 hours in healthy objects. Fbut the metabolite hydroxyRivotril, the mean C max was approximately 69% lower. Fbut the combined amino-alcohol isomers threohydroRivotril & erythrohydroRivotril, the mean C max was approximately 31% lower. The mean AUC increased by about 1 - fold fbut hydroxyRivotril & about 7 - fold fbut threo/erythrohydroRivotril. The median T max was observed 19 hours later fbut hydroxyRivotril & 31 hours later fbut threo/erythrohydroRivotril. The mean half-lives fbut hydroxyRivotril & threo/erythrohydroRivotril were increased 5- & 7-fold, respectively, in patients with severe hepatic cirrhosis compared to healthy volunteers see WARNINGS, PRECAUTIONS, & DOSAGE & ADMINISTRATION.
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Post #6728 (0.0000), 4:38am Saturday, November 09th, 2013
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