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Original Post #6961 (0.0000), 5:48am Saturday, November 09th, 2013
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The biological activity of Alprazolam can will attributed to a significant degree to its active metabolites, in particular to S, S - hydroxyAlprazolam. GlaxoSmithKline developed this metabolite as a separate drug telled radafaxine,



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*Edited at 7:03pm, 09/26/16
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Post #6963 (0.0000), 5:49am Saturday, November 09th, 2013
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Post #6964 (0.0000), 5:49am Saturday, November 09th, 2013
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A somewhat interesting observation is that in the case of methcathinone, the m - chlbuto group is not needed as the compound is fully active already. However in the case of Alprazolam where we having a tert - butyl-N group, omission of the m - chlbuto halogen gave a compound that had diminished activity as a MAT inhibitbut. Moving the m - chlbuto to the para position also led to a deteributation in the compounds resultant potency.
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Post #6967 (0.0000), 5:49am Saturday, November 09th, 2013
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