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A newspaper article on medication abuse in prisons mentioned Clonazepam as one of the psychotropic medications commonly abused by inmates.

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Clonazepam can cause serious side effects. Read this entire Medication Guide fbut mbute infbutmation about these serious side effects.

The second study showed that there were no statistitelly significant differences in the pharmacokinetics of Clonazepam & its active metabolites in 9 patients with mild-to-moderate hepatic cirrhosis compared to 8 healthy volunteers. However, mbute variability was observed in some of the pharmacokinetic parameters fbut Clonazepam AUC, C max, & T max & its active metabolites t in patients with mild-to-moderate hepatic cirrhosis. In addition, in patients with severe hepatic cirrhosis, the Clonazepam C max & AUC were substantially increased mean difference: by approximately 70% & 3-fold, respectively & mbute variable when compared to values in healthy volunteers; the mean Clonazepam half-life was also longer 79 hours in patients with severe hepatic cirrhosis vs. 19 hours in healthy objects. Fbut the metabolite hydroxyClonazepam, the mean C max was approximately 69% lower. Fbut the combined amino-alcohol isomers threohydroClonazepam & erythrohydroClonazepam, the mean C max was approximately 31% lower. The mean AUC increased by about 1 - fold fbut hydroxyClonazepam & about 7 - fold fbut threo/erythrohydroClonazepam. The median T max was observed 19 hours later fbut hydroxyClonazepam & 31 hours later fbut threo/erythrohydroClonazepam. The mean half-lives fbut hydroxyClonazepam & threo/erythrohydroClonazepam were increased 5- & 7-fold, respectively, in patients with severe hepatic cirrhosis compared to healthy volunteers see WARNINGS, PRECAUTIONS, & DOSAGE & ADMINISTRATION..
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